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Cropped view of the EPSOLAY cream bottle on the right with EPSOLAY cream smeared on the left

4 steps to skincare success

EPSOLAY cream is designed to be delicate on skin, so you can apply it every day as prescribed, either in the morning or evening.1

USING EPSOLAY CREAM IS AS EASY AS C-A-M-P:

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Woman with rosacea in her mid-30s cupping water in both hands and raising to face
1
Cleanse

Use a mild cleanser like Cetaphil® Gentle Skin Cleanser, gently rinse your face, and pat completely dry with a soft towel.1

Woman with rosacea in her mid-30s putting pea-sized amount of EPSOLAY cream on left cheek
2
Apply

Lightly massage a pea-sized amount of EPSOLAY cream onto each area of your face (forehead, chin, nose, and cheeks). Avoid your eyes, lips, and mouth and let dry.1

Wash your hands, as the cream may stain or bleach fabric.1

Woman with rosacea in her mid-30s touching hand to left cheek
3
Moisturize

After the medication has dried, use a moisturizer like Cetaphil® Moisturizing Lotion.1

Face of a woman with rosacea in her mid-30s looking forward
4
Protect

If you decide to use EPSOLAY cream as part of your morning routine, be sure to use a daily sunscreen to protect your skin!1

  • Tips for using
    EPSOLAY cream1

  • Illustration of EPSOLAY cream bottle

    Before you use EPSOLAY cream for the first time, prime the pump by pressing down until the first drop of cream is dispensed.

  • Illustration of sun with rays

    Make sure to limit your time in sunlight or artificial light. EPSOLAY cream may make your skin more sensitive to the sun and the light.

  • Illustration of EPSOLAY cream bottle with cap on

    Your bottle of EPSOLAY cream should be stored at room temperature (68 ℉ to 77 ℉).

  • Illustration of trash can with lid

    Please discard your bottle of EPSOLAY cream 30 days after your first use or by the expiration date printed on the bottle, whichever comes first.

  • Illustration of EPSOLAY cream bottle with cap on encompassed by cyclical arrows

    Be sure to refill EPSOLAY cream right away, so you can continue to use it after your bottle is finished.

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Reference: 1. EPSOLAY (benzoyl peroxide) cream, 5% [Prescribing Information]. Whippany, NJ: Sol-Gel Technologies Ltd.; April 2021.

IMPORTANT SAFETY INFORMATION

Indication: EPSOLAY® (benzoyl peroxide) Cream, 5% is indicated for the treatment of inflammatory lesions of rosacea in adults. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with EPSOLAY Cream were pain, erythema (redness), pruritus (itching) and edema (swelling), all at the application site. Warnings/Precautions: Patients using EPSOLAY Cream may experience hypersensitivity reactions, including anaphylaxis (acute allergic reaction), angioedema (rapid swelling), and urticaria (hives). If serious hypersensitivity reaction occurs, discontinue use of EPSOLAY Cream immediately and seek medical attention/initiate appropriate therapy. Skin Irritation/contact dermatitis may be experienced, including erythema (redness), scaling, dryness, and stinging/burning. Irritation and contact dermatitis may occur. Use a moisturizer and discontinue EPSOLAY Cream if symptoms do not improve. Avoid application to cuts, abrasions, eczematous, or sunburned skin. EPSOLAY Cream may increase photosensitivity, sensitivity to ultraviolet light. Minimize or avoid exposure to natural or artificial sunlight (tanning beds or UVA/B treatment). Use sunscreen or protective clothing when sun exposure cannot be avoided. Discontinue use of EPSOLAY Cream at the first evidence of sunburn.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088

IMPORTANT SAFETY INFORMATION

Indication: EPSOLAY® (benzoyl peroxide) Cream, 5% is indicated for the treatment of inflammatory lesions of rosacea in adults. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with EPSOLAY Cream were pain, erythema (redness), pruritus (itching) and edema (swelling), all at the application site. Warnings/Precautions: Patients using EPSOLAY Cream may experience hypersensitivity reactions, including anaphylaxis (acute allergic reaction), angioedema (rapid swelling), and urticaria (hives). If serious hypersensitivity reaction occurs, discontinue use of EPSOLAY Cream immediately and seek medical attention/initiate appropriate therapy. Skin Irritation/contact dermatitis may be experienced, including erythema (redness), scaling, dryness, and stinging/burning. Irritation and contact dermatitis may occur. Use a moisturizer and discontinue EPSOLAY Cream if symptoms do not improve. Avoid application to cuts, abrasions, eczematous, or sunburned skin. EPSOLAY Cream may increase photosensitivity, sensitivity to ultraviolet light. Minimize or avoid exposure to natural or artificial sunlight (tanning beds or UVA/B treatment). Use sunscreen or protective clothing when sun exposure cannot be avoided. Discontinue use of EPSOLAY Cream at the first evidence of sunburn.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088

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