Capturing rosacea relief with EPSOLAY cream

EPSOLAY cream is a groundbreaking topical treatment designed to help alleviate the bumps and blemishes of rosacea.1–3

The power of EPSOLAY cream

Designed for sensitive rosacea skin1

EPSOLAY cream’s innovative microencapsulation technology offers the potential of benzoyl peroxide (BPO) with previously unattained tolerability for rosacea patients.1,2

Explore EPSOLAY cream
EPSOLAY packaging

Microencapsulation technology

EPSOLAY cream’s microcapsules gradually release BPO to relieve rosacea while remaining tolerable.

How it works
Graphical representation of microencapsulation

Real results

Patients noticed clearer skin in as little as 2 weeks during a clinical study looking primarily at BPO efficacy for inflammatory rosacea lesions over 12 weeks.2
 

Not an actual patient.

See the results
Woman with rosacea smiling

How to apply EPSOLAY cream

Designed for sensitive rosacea skin, EPSOLAY cream can be an effective daily treatment to soothe symptoms.

4 steps toward rosacea relief
EPSOLAY cream on someone's palm. Their other hand is dabbing it to apply to their face.

References: 

  1. EPSOLAY (benzoyl peroxide) cream, 5% [prescribing information]. Raleigh (NC): Mayne Pharma; revised 2025 Feb.
  2. Bhatia N, Werschler WP, Baldwin H, Sugarman J, Green LJ, Levy-Hacham O, et al. Efficacy and safety of microencapsulated benzoyl peroxide cream, 5%, in rosacea: results from two phase III, randomized, vehicle-controlled trials. J Clin Aesthet Dermatol. 2023;16(8):34-40.
  3. Leyden JJ. Randomized, phase 2, dose-ranging study in the treatment of rosacea with encapsulated benzoyl peroxide gel. J Drugs Dermatol. 2014;13(6):685-88.

Important Safety Information

Indications and usage: EPSOLAY® (benzoyl peroxide) cream, 5% is indicated for the treatment of inflammatory lesions of rosacea in adults.

Contraindications: A history of hypersensitivity reactions to benzoyl peroxide or any component of the formulation in EPSOLAY.

Warnings and precautions: 

  • Hypersensitivity: Severe hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with the use of benzoyl peroxide products.
  • Skin irritation/contact dermatitis: Erythema, scaling, dryness, stinging/burning, irritation and allergic contact dermatitis may occur with the use of EPSOLAY and may necessitate discontinuation.
  • Photosensitivity: Avoid or minimize exposure to natural or artificial sunlight and use sun protection measures.

Adverse reactions: Most common adverse reactions (incidence ≥1%) are application site reactions: pain erythema, pruritus, and edema.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.